Temperature-dependent splicing of β-globin pre-mRNA
A T→G mutation at nucleotide 705 of human β-globin intron 2 creates an aberrant 5′ splice site and activates a cryptic 3′ splice site upstream. In consequence, the pre-mRNA is spliced via aberrant splice sites, despite the presence of the still functional correct sites. Surprisingly, when IVS2-705 H...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12409448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf607 |
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