Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine
In fragile X syndrome, hypermethylation of the expanded CGG repeat and of the upstream promoter leads to transcriptional silencing of the FMR1 gene. Absence of the FMR1 protein results in mental retardation. We previously proved that treatment with 5-azadeoxycytidine (5-azadC) of fragile X cell line...
সংরক্ষণ করুন:
| প্রকাশিত: | Nucleic Acids Res |
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| প্রধান লেখক: | , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Oxford University Press
2002
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135754/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12136110/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf434 |
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