Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine

In fragile X syndrome, hypermethylation of the expanded CGG repeat and of the upstream promoter leads to transcriptional silencing of the FMR1 gene. Absence of the FMR1 protein results in mental retardation. We previously proved that treatment with 5-azadeoxycytidine (5-azadC) of fragile X cell line...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Pietrobono, Roberta, Pomponi, Maria Grazia, Tabolacci, Elisabetta, Oostra, Ben, Chiurazzi, Pietro, Neri, Giovanni
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135754/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12136110/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf434
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