Immunization with Chaperone-Peptide Complex Induces Low-Avidity Cytotoxic T Lymphocytes Providing Transient Protection against Herpes Simplex Virus Infection

Heat shock proteins loaded with viral peptides were shown to induce a CD8(+) T cell response and confer protective immunity against challenge with herpes simplex virus (HSV). The delivery system consisted of recombinant human hsp70 coupled to the peptide SSIEFARL, which is the immunodominant peptide...

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Bibliografiset tiedot
Päätekijät: Kumaraguru, Udayasankar, Gierynska, Malgorzata, Norman, Shanna, Bruce, Barry D., Rouse, Barry T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2002
Aiheet:
Vaccines and Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC135705/
https://ncbi.nlm.nih.gov/pubmed/11739679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.1.136-141.2002
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