Induction of CD8 T-Cell-Specific Systemic and Mucosal Immunity against Herpes Simplex Virus with CpG-Peptide Complexes

Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs exert powerful adjuvant activity in vivo and in vitro. Administered with antigen they induce a population of antigen-specific CD8(+) T cells. In this study we immunized C57BL/6 mice with bioactive CpG ODN combined with an immunodominant...

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Autores principales: Gierynska, Malgorzata, Kumaraguru, Uday, Eo, Seong-Kug, Lee, Sujin, Krieg, Arthur, Rouse, Barry T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136257/
https://ncbi.nlm.nih.gov/pubmed/12050369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.13.6568-6576.2002
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