Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved in postembryonic neurogenesis in flies. Because of its mapping position on chromosome 21 and the neurobehavioral alterations shown by mice overexpressing this gene, involvement of DYRK1A in some of the neurologi...

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Detalhes bibliográficos
Main Authors: Fotaki, Vassiliki, Dierssen, Mara, Alcántara, Soledad, Martínez, Salvador, Martí, Eulàlia, Casas, Caty, Visa, Joana, Soriano, Eduardo, Estivill, Xavier, Arbonés, Maria L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135639/
https://ncbi.nlm.nih.gov/pubmed/12192061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.18.6636-6647.2002
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