Transketolase Haploinsufficiency Reduces Adipose Tissue and Female Fertility in Mice

Transketolase (TKT) is a ubiquitous enzyme used in multiple metabolic pathways. We show here by gene targeting that TKT-null mouse embryos are not viable and that disruption of one TKT allele can cause growth retardation (≈35%) and preferential reduction of adipose tissue (≈77%). Other TKT(+/−) tiss...

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Detalhes bibliográficos
Main Authors: Xu, Zheng-Ping, Wawrousek, Eric F., Piatigorsky, Joram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134013/
https://ncbi.nlm.nih.gov/pubmed/12167708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6142-6147.2002
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