Transketolase Haploinsufficiency Reduces Adipose Tissue and Female Fertility in Mice

Transketolase (TKT) is a ubiquitous enzyme used in multiple metabolic pathways. We show here by gene targeting that TKT-null mouse embryos are not viable and that disruption of one TKT allele can cause growth retardation (≈35%) and preferential reduction of adipose tissue (≈77%). Other TKT(+/−) tiss...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Xu, Zheng-Ping, Wawrousek, Eric F., Piatigorsky, Joram
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134013/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6142-6147.2002
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