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Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

BACKGROUND: Pathogenic aneuploidies involve the concept of dosage-sensitive genes leading to over- and underexpression phenotypes. Monosomy 21 in human leads to mental retardation and skeletal, immune and respiratory function disturbances. Most of the human condition corresponds to partial monosomie...

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Bibliografiske detaljer
Main Authors: Arqué, Glòria, Fotaki, Vassiliki, Fernández, David, de Lagrán, María Martínez, Arbonés, Maria L., Dierssen, Mara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481280/
https://ncbi.nlm.nih.gov/pubmed/18648535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002575
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