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Structural insight into poly(A) binding and catalytic mechanism of human PARN
Poly(A)-specific ribonuclease (PARN) is a processive, poly(A)-specific 3′ exoribonuclease. The crystal structure of C-terminal truncated human PARN determined in two states (free and RNA-bound forms) reveals that PARNn is folded into two domains, an R3H domain and a nuclease domain similar to those...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356309/ https://ncbi.nlm.nih.gov/pubmed/16281054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600869 |
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