Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA

During polyadenylation of mRNA precursors in metazoan cells, poly(A) polymerase is stimulated by the nuclear poly(A) binding protein PABPN1. We report that stimulation depends on binding of PABPN1 to the substrate RNA directly adjacent to poly(A) polymerase and results in an ∼80-fold increase in the...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Kerwitz, Yvonne, Kühn, Uwe, Lilie, Hauke, Knoth, Anne, Scheuermann, Till, Friedrich, Henning, Schwarz, Elisabeth, Wahle, Elmar
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC165617/
https://ncbi.nlm.nih.gov/pubmed/12853485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg347
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares