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Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding
Rad2/XPG belongs to the flap nuclease family and is responsible for a key step of the eukaryotic nucleotide excision DNA repair (NER) pathway. To elucidate the mechanism of DNA binding by Rad2/XPG, we solved crystal structures of the catalytic core of Rad2 in complex with a substrate. Rad2 utilizes...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176360/ https://ncbi.nlm.nih.gov/pubmed/25120270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku729 |
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