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Structural insights into the catalytic mechanism of lovastatin hydrolase
The lovastatin hydrolase PcEST from the fungus Penicillium chrysogenum exhibits enormous potential for industrial-scale applications in single-step production of monacolin J, the key precursor for synthesis of the cholesterol-lowering drug simvastatin. This enzyme specifically and efficiently cataly...
Gespeichert in:
| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983846/ https://ncbi.nlm.nih.gov/pubmed/31839596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011936 |
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