The Chinese Hamster Dihydrofolate Reductase Replication Origin Decision Point Follows Activation of Transcription and Suppresses Initiation of Replication within Transcription Units

Chinese hamster ovary (CHO) cells select specific replication origin sites within the dihydrofolate reductase (DHFR) locus at a discrete point during G(1) phase, the origin decision point (ODP). Origin selection is sensitive to transcription but not protein synthesis inhibitors, implicating a pretra...

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Hauptverfasser: Sasaki, Takayo, Ramanathan, Sunita, Okuno, Yukiko, Kumagai, Chiharu, Shaikh, Seemab S., Gilbert, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1347040/
https://ncbi.nlm.nih.gov/pubmed/16428457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.3.1051-1062.2006
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