Perforin-Deficient CD8(+) T Cells Mediate Fatal Lymphocytic Choriomeningitis despite Impaired Cytokine Production

Intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) is one of the most studied models for virus-induced immunopathology, and based on results from perforin-deficient mice, it is currently assumed that fatal disease directly reflects perforin-mediated cell lysis. However, re...

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Bibliographic Details
Main Authors: Storm, Pernille, Bartholdy, Christina, Sørensen, Maria Rathman, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346958/
https://ncbi.nlm.nih.gov/pubmed/16414999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1222-1230.2006
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