Perforin and Fas Act Together in the Induction of Apoptosis, and Both Are Critical in the Clearance of Lymphocytic Choriomeningitis Virus Infection

In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles. For this purpose we have analyzed the response of mice that lack Fas as well as granzyme A (gzmA) and...

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Bibliographic Details
Main Authors: Rode, Miriam, Balkow, Sandra, Sobek, Vera, Brehm, Reina, Martin, Praxedis, Kersten, Astrid, Dumrese, Tilman, Stehle, Thomas, Müllbacher, Arno, Wallich, Reinhard, Simon, Markus M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC525048/
https://ncbi.nlm.nih.gov/pubmed/15507626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12395-12405.2004
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