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Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ(1)34.5 Mutants of Herpes Simplex Virus 1
Herpes simplex virus mutants lacking the γ(1)34.5 gene are not destructive to normal tissues but are potent cytolytic agents in human tumor cells in which the activation of double-stranded RNA-dependent protein kinase (PKR) is suppressed. Thus, replication of a Δγ(1)34.5 mutant (R3616) in 12 genetic...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1346955/ https://ncbi.nlm.nih.gov/pubmed/16414988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1110-1120.2006 |
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