Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ(1)34.5 Mutants of Herpes Simplex Virus 1

Herpes simplex virus mutants lacking the γ(1)34.5 gene are not destructive to normal tissues but are potent cytolytic agents in human tumor cells in which the activation of double-stranded RNA-dependent protein kinase (PKR) is suppressed. Thus, replication of a Δγ(1)34.5 mutant (R3616) in 12 genetic...

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Main Authors: Smith, Kerrington D., Mezhir, James J., Bickenbach, Kai, Veerapong, Jula, Charron, Jean, Posner, Mitchell C., Roizman, Bernard, Weichselbaum, Ralph R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346955/
https://ncbi.nlm.nih.gov/pubmed/16414988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1110-1120.2006
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