Rap1A-Deficient T and B Cells Show Impaired Integrin-Mediated Cell Adhesion

Studies in tissue culture cells have demonstrated a role for the Ras-like GTPase Rap1 in the regulation of integrin-mediated cell-matrix and cadherin-mediated cell-cell contacts. To analyze the function of Rap1 in vivo, we have disrupted the Rap1A gene by homologous recombination. Mice homozygous fo...

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Hlavní autoři: Duchniewicz, Marlena, Zemojtel, Tomasz, Kolanczyk, Mateusz, Grossmann, Steffen, Scheele, Jürgen S., Zwartkruis, Fried J. T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346907/
https://ncbi.nlm.nih.gov/pubmed/16382154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.2.643-653.2006
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