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Construction and Immunological Characterization of a Novel Nontoxic Protective Pneumolysin Mutant for Use in Future Pneumococcal Vaccines

Pneumolysin, the pore-forming toxin produced by Streptococcus pneumoniae, may have an application as an immunogenic carrier protein in future pneumococcal conjugate vaccines. Most of the 90 S. pneumoniae serotypes identified produce pneumolysin; therefore, this protein may confer non-serotype-specif...

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Detalhes bibliográficos
Main Authors: Kirkham, Lea-Ann S., Kerr, Alison R., Douce, Gill R., Paterson, Gavin K., Dilts, Deborah A., Liu, Dai-Fang, Mitchell, Tim J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346677/
https://ncbi.nlm.nih.gov/pubmed/16369015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.1.586-593.2006
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