p19(ARF) Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

Recent studies have shown the p19(ARF) tumor suppressor to be involved in the response to oncogenic stress by regulating the activity of p53. This response is mediated by antagonizing the function of Mdm2, a negative regulator of p53, indicating a pathway for tumor suppression that involves numerous...

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Bibliographic Details
Main Authors: Tolbert, Dawn, Lu, Xiangdong, Yin, Chaoying, Tantama, Mathew, Van Dyke, Terry
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134227/
https://ncbi.nlm.nih.gov/pubmed/11739748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.1.370-377.2002
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