Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability

We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT(121) mice, cell-specific inactivation of the pRb pathway in brain choroid plexus epithelium initiates tumorigenesis and induces p53-dependent apopto...

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Detalhes bibliográficos
Main Authors: Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87319/
https://ncbi.nlm.nih.gov/pubmed/11486039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.6017-6030.2001
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