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Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT(121) mice, cell-specific inactivation of the pRb pathway in brain choroid plexus epithelium initiates tumorigenesis and induces p53-dependent apopto...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC87319/ https://ncbi.nlm.nih.gov/pubmed/11486039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.6017-6030.2001 |
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