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c-Myc Functionally Cooperates with Bax To Induce Apoptosis

c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family. We show here that fibroblasts lacking Bak remain susceptible...

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Publicado no:Mol Cell Biol
Principais autores: Juin, Philippe, Hunt, Abigail, Littlewood, Trevor, Griffiths, Beatrice, Brown Swigart, Lamorna, Korsmeyer, Stanley, Evan, Gerard
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133996/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167710/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6158-6169.2002
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