c-Myc Functionally Cooperates with Bax To Induce Apoptosis

c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family. We show here that fibroblasts lacking Bak remain susceptible...

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Autori principali: Juin, Philippe, Hunt, Abigail, Littlewood, Trevor, Griffiths, Beatrice, Brown Swigart, Lamorna, Korsmeyer, Stanley, Evan, Gerard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133996/
https://ncbi.nlm.nih.gov/pubmed/12167710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6158-6169.2002
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