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Regulation of the Transcription Factor Gcn4 by Pho85 Cyclin Pcl5

The yeast transcription factor Gcn4 is regulated by amino acid starvation at the levels of both protein synthesis and stability. Gcn4 degradation depends on the ubiquitination complex SCF(CDC4) and requires phosphorylation by the cyclin-dependent kinase Pho85. Here, we show that Pcl5 is the Pho85 cy...

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Autori principali: Shemer, Revital, Meimoun, Ariella, Holtzman, Tsvi, Kornitzer, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133946/
https://ncbi.nlm.nih.gov/pubmed/12101234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5395-5404.2002
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