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Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis
The Cdc6 DNA replication initiation factor is targeted for ubiquitin-mediated proteolysis by the E3 ubiquitin ligase SCF(CDC4) from the end of G(1) phase until mitosis in the budding yeast Saccharomyces cerevisiae. Here we describe a dominant-negative CDC6 mutant that, when overexpressed, arrests th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125267/ https://ncbi.nlm.nih.gov/pubmed/11532947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4836 |
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