Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis

The Cdc6 DNA replication initiation factor is targeted for ubiquitin-mediated proteolysis by the E3 ubiquitin ligase SCF(CDC4) from the end of G(1) phase until mitosis in the budding yeast Saccharomyces cerevisiae. Here we describe a dominant-negative CDC6 mutant that, when overexpressed, arrests th...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Perkins, Gordon, Drury, Lucy S., Diffley, John F.X.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4836
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