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Cell Attachment to the Extracellular Matrix Induces Proteasomal Degradation of p21(CIP1) via Cdc42/Rac1 Signaling
The cyclin-dependent kinase 2 (Cdk2) inhibitors p21(CIP1) and p27(KIP1) are negatively regulated by anchorage during cell proliferation, but it is unclear how integrin signaling may affect these Cdk2 inhibitors. Here, we demonstrate that integrin ligation led to rapid reduction of p21(CIP1) and p27(...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133897/ https://ncbi.nlm.nih.gov/pubmed/12052868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4587-4597.2002 |
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