Cell Attachment to the Extracellular Matrix Induces Proteasomal Degradation of p21(CIP1) via Cdc42/Rac1 Signaling

The cyclin-dependent kinase 2 (Cdk2) inhibitors p21(CIP1) and p27(KIP1) are negatively regulated by anchorage during cell proliferation, but it is unclear how integrin signaling may affect these Cdk2 inhibitors. Here, we demonstrate that integrin ligation led to rapid reduction of p21(CIP1) and p27(...

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Bibliografiska uppgifter
Huvudupphovsmän: Bao, Wenjie, Thullberg, Minna, Zhang, Hongquan, Onischenko, Anatoli, Strömblad, Staffan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC133897/
https://ncbi.nlm.nih.gov/pubmed/12052868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4587-4597.2002
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