Cell Attachment to the Extracellular Matrix Induces Proteasomal Degradation of p21(CIP1) via Cdc42/Rac1 Signaling

The cyclin-dependent kinase 2 (Cdk2) inhibitors p21(CIP1) and p27(KIP1) are negatively regulated by anchorage during cell proliferation, but it is unclear how integrin signaling may affect these Cdk2 inhibitors. Here, we demonstrate that integrin ligation led to rapid reduction of p21(CIP1) and p27(...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bao, Wenjie, Thullberg, Minna, Zhang, Hongquan, Onischenko, Anatoli, Strömblad, Staffan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2002
Gaiak:
Cell Growth and Development
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC133897/
https://ncbi.nlm.nih.gov/pubmed/12052868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4587-4597.2002
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak