DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Autori principali: Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133764/
https://ncbi.nlm.nih.gov/pubmed/11940649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.2906-2917.2002
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