DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Bibliografiset tiedot
Päätekijät: Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2002
Aiheet:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC133764/
https://ncbi.nlm.nih.gov/pubmed/11940649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.2906-2917.2002
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