DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Detalhes bibliográficos
Main Authors: Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133764/
https://ncbi.nlm.nih.gov/pubmed/11940649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.2906-2917.2002
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