DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11940649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.9.2906-2917.2002
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