DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2002
Matèries:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11940649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.9.2906-2917.2002
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