DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

I whakaputaina i:	Mol Cell Biol
Ngā kaituhi matua:	Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Taylor & Francis 2002
Ngā marau:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11940649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.9.2906-2917.2002
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!