DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation but...

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Detaylı Bibliyografya
Asıl Yazarlar: Trinh, Binh N., Long, Tiffany I., Nickel, Andrea E., Shibata, Darryl, Laird, Peter W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2002
Konular:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC133764/
https://ncbi.nlm.nih.gov/pubmed/11940649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.2906-2917.2002
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