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Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo
The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic v...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133738/ https://ncbi.nlm.nih.gov/pubmed/11909960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2663-2672.2002 |
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