Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo

The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic v...

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Main Authors: Cloud, Jennifer E., Rogers, Catherine, Reza, Tammi L., Ziebold, Ulrike, Stone, James R., Picard, Michael H., Caron, Alicia M., Bronson, Roderick T., Lees, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC133738/
https://ncbi.nlm.nih.gov/pubmed/11909960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2663-2672.2002
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