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hMutSβ Is Required for the Recognition and Uncoupling of Psoralen Interstrand Cross-Links In Vitro

The removal of interstrand cross-links (ICLs) from DNA in higher eucaryotes is not well understood. Here, we show that processing of psoralen ICLs in mammalian cell extracts is dependent upon the mismatch repair complex hMutSβ but is not dependent upon the hMutSα complex or hMlh1. The processing of...

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Udgivet i:Mol Cell Biol
Principais autores: Zhang, Nianxiang, Lu, Xiaoyan, Zhang, Xiaoshan, Peterson, Carolyn A., Legerski, Randy J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133700/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884621/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.2388-2397.2002
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