The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins

Activation of RAS proteins can lead to multiple outcomes by virtue of regulated signal traffic through alternate effector pathways. We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity (K(d), 22 nM) similar to that observed for RAF1. At concentrations close to th...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Wang, Ying, Waldron, Richard T., Dhaka, Ajay, Patel, Apoor, Riley, Maggie M., Rozengurt, Enrique, Colicelli, John
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11784866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.3.916-926.2001
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