An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.

Samankaltaisia teoksia

• Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
  Tekijä: Chuang, E, et al.
  Julkaistu: (1994)
• A human Raf-responsive zinc-finger protein that binds to divergent sequences.
  Tekijä: Zhang, L, et al.
  Julkaistu: (1999)
• BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila
  Tekijä: Doggett, Karen, et al.
  Julkaistu: (2015)
• KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
  Tekijä: Tran, Timothy H., et al.
  Julkaistu: (2021)
• Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity
  Tekijä: Kiel, Christina, et al.
  Julkaistu: (2009)