The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins

Activation of RAS proteins can lead to multiple outcomes by virtue of regulated signal traffic through alternate effector pathways. We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity (K(d), 22 nM) similar to that observed for RAF1. At concentrations close to th...

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Detalhes bibliográficos
Main Authors: Wang, Ying, Waldron, Richard T., Dhaka, Ajay, Patel, Apoor, Riley, Maggie M., Rozengurt, Enrique, Colicelli, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133556/
https://ncbi.nlm.nih.gov/pubmed/11784866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.3.916-926.2001
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