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The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins
Activation of RAS proteins can lead to multiple outcomes by virtue of regulated signal traffic through alternate effector pathways. We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity (K(d), 22 nM) similar to that observed for RAF1. At concentrations close to th...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133556/ https://ncbi.nlm.nih.gov/pubmed/11784866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.3.916-926.2001 |
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