The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins

Activation of RAS proteins can lead to multiple outcomes by virtue of regulated signal traffic through alternate effector pathways. We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity (K(d), 22 nM) similar to that observed for RAF1. At concentrations close to th...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Wang, Ying, Waldron, Richard T., Dhaka, Ajay, Patel, Apoor, Riley, Maggie M., Rozengurt, Enrique, Colicelli, John
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11784866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.3.916-926.2001
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