Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion

The uptake of [(3)H]pentamidine into wild-type and drug-resistant strains of Leishmania mexicana was compared. Uptake was carrier mediated. Pentamidine-resistant parasites showed cross-resistance to other toxic diamidine derivatives. A substantial decrease in accumulation of the drug accompanied the...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Basselin, Mireille, Denise, Hubert, Coombs, Graham H., Barrett, Michael P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC132791/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12435669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.12.3731-3738.2002
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