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Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion

The uptake of [(3)H]pentamidine into wild-type and drug-resistant strains of Leishmania mexicana was compared. Uptake was carrier mediated. Pentamidine-resistant parasites showed cross-resistance to other toxic diamidine derivatives. A substantial decrease in accumulation of the drug accompanied the...

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Bibliografische gegevens
Hoofdauteurs: Basselin, Mireille, Denise, Hubert, Coombs, Graham H., Barrett, Michael P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2002
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC132791/
https://ncbi.nlm.nih.gov/pubmed/12435669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3731-3738.2002
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