Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

Autoantibody-mediated tissue destruction is among the main features of organ-specific autoimmunity. This report describes “an antibody enzyme” (abzyme) contribution to the site-specific degradation of a neural antigen. We detected proteolytic activity toward myelin basic protein (MBP) in the fractio...

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Main Authors: Ponomarenko, Natalia A., Durova, Oxana M., Vorobiev, Ivan I., Belogurov, Alexey A., Kurkova, Inna N., Petrenko, Alexander G., Telegin, Georgy B., Suchkov, Sergey V., Kiselev, Sergey L., Lagarkova, Maria A., Govorun, Vadim M., Serebryakova, Marina V., Avalle, Bérangère, Tornatore, Pete, Karavanov, Alexander, Morse, Herbert C., Thomas, Daniel, Friboulet, Alain, Gabibov, Alexander G.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324791/
https://ncbi.nlm.nih.gov/pubmed/16387849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509849103
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