Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

Autoantibody-mediated tissue destruction is among the main features of organ-specific autoimmunity. This report describes “an antibody enzyme” (abzyme) contribution to the site-specific degradation of a neural antigen. We detected proteolytic activity toward myelin basic protein (MBP) in the fractio...

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Detalhes bibliográficos
Main Authors: Ponomarenko, Natalia A., Durova, Oxana M., Vorobiev, Ivan I., Belogurov, Alexey A., Kurkova, Inna N., Petrenko, Alexander G., Telegin, Georgy B., Suchkov, Sergey V., Kiselev, Sergey L., Lagarkova, Maria A., Govorun, Vadim M., Serebryakova, Marina V., Avalle, Bérangère, Tornatore, Pete, Karavanov, Alexander, Morse, Herbert C., Thomas, Daniel, Friboulet, Alain, Gabibov, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324791/
https://ncbi.nlm.nih.gov/pubmed/16387849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509849103
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