Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

Autoantibody-mediated tissue destruction is among the main features of organ-specific autoimmunity. This report describes “an antibody enzyme” (abzyme) contribution to the site-specific degradation of a neural antigen. We detected proteolytic activity toward myelin basic protein (MBP) in the fractio...

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Main Authors: Ponomarenko, Natalia A., Durova, Oxana M., Vorobiev, Ivan I., Belogurov, Alexey A., Kurkova, Inna N., Petrenko, Alexander G., Telegin, Georgy B., Suchkov, Sergey V., Kiselev, Sergey L., Lagarkova, Maria A., Govorun, Vadim M., Serebryakova, Marina V., Avalle, Bérangère, Tornatore, Pete, Karavanov, Alexander, Morse, Herbert C., Thomas, Daniel, Friboulet, Alain, Gabibov, Alexander G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2006
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324791/
https://ncbi.nlm.nih.gov/pubmed/16387849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509849103
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