Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

Autoantibody-mediated tissue destruction is among the main features of organ-specific autoimmunity. This report describes “an antibody enzyme” (abzyme) contribution to the site-specific degradation of a neural antigen. We detected proteolytic activity toward myelin basic protein (MBP) in the fractio...

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Detalles Bibliográficos
Autores principales: Ponomarenko, Natalia A., Durova, Oxana M., Vorobiev, Ivan I., Belogurov, Alexey A., Kurkova, Inna N., Petrenko, Alexander G., Telegin, Georgy B., Suchkov, Sergey V., Kiselev, Sergey L., Lagarkova, Maria A., Govorun, Vadim M., Serebryakova, Marina V., Avalle, Bérangère, Tornatore, Pete, Karavanov, Alexander, Morse, Herbert C., Thomas, Daniel, Friboulet, Alain, Gabibov, Alexander G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324791/
https://ncbi.nlm.nih.gov/pubmed/16387849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509849103
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