Routes to covalent catalysis by reactive selection for nascent protein nucleophiles

Reactivity-based selection strategies have been used to enrich combinatorial libraries for encoded biocatalysts having revised substrate specificity or altered catalytic activity. This approach can also assist in artificial evolution of enzyme catalysis from protein templates without bias for predef...

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Autores principales: Reshetnyak, Andrey V., Armentano, Maria Francesca, Ponomarenko, Natalia A., Vizzuso, Domenica, Durova, Oxana M., Ziganshin, Rustam, Serebryakova, Marina, Govorun, Vadim, Gololobov, Gennady, Morse III, Herbert C., Friboulet, Alain, Makker, Sudesh P., Gabibov, Alexander G., Tramontano, Alfonso
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527816/
https://ncbi.nlm.nih.gov/pubmed/18044899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076528m
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