Routes to covalent catalysis by reactive selection for nascent protein nucleophiles

Reactivity-based selection strategies have been used to enrich combinatorial libraries for encoded biocatalysts having revised substrate specificity or altered catalytic activity. This approach can also assist in artificial evolution of enzyme catalysis from protein templates without bias for predef...

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Detalhes bibliográficos
Main Authors: Reshetnyak, Andrey V., Armentano, Maria Francesca, Ponomarenko, Natalia A., Vizzuso, Domenica, Durova, Oxana M., Ziganshin, Rustam, Serebryakova, Marina, Govorun, Vadim, Gololobov, Gennady, Morse III, Herbert C., Friboulet, Alain, Makker, Sudesh P., Gabibov, Alexander G., Tramontano, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527816/
https://ncbi.nlm.nih.gov/pubmed/18044899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076528m
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