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A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function
The adapter SLP-76 is essential for T cell development and function. SLP-76 binds to the src homology 3 domain of Lck in vitro. This interaction depends on amino acids 185–194 of SLP-76. To examine the role of the Lck-binding region of SLP-76 in T cell development and function, SLP-76(-/-) mice were...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1323183/ https://ncbi.nlm.nih.gov/pubmed/16354835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509176102 |
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