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A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function

The adapter SLP-76 is essential for T cell development and function. SLP-76 binds to the src homology 3 domain of Lck in vitro. This interaction depends on amino acids 185–194 of SLP-76. To examine the role of the Lck-binding region of SLP-76 in T cell development and function, SLP-76(-/-) mice were...

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Autors principals: Kumar, Lalit, Feske, Stefan, Rao, Anjana, Geha, Raif S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323183/
https://ncbi.nlm.nih.gov/pubmed/16354835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509176102
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