Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

Dysfunction of mitochondrial complex I is a feature of human neurodegenerative diseases such as Leber hereditary optic neuropathy and Parkinson's disease. This mitochondrial defect is associated with a recruitment of the mitochondrial-dependent apoptotic pathway in vivo. However, in isolated br...

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Bibliografische gegevens
Hoofdauteurs: Perier, Celine, Tieu, Kim, Guégan, Christelle, Caspersen, Casper, Jackson-Lewis, Vernice, Carelli, Valerio, Martinuzzi, Andrea, Hirano, Michio, Przedborski, Serge, Vila, Miquel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323177/
https://ncbi.nlm.nih.gov/pubmed/16365298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508215102
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